Topical diphenyl diselenide mice research

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August undefined, 2024

WebBisphenol A (BPA) is a chemical toxicant that has deleterious effects on human. BPA causes oxidative stress in tissues, including the liver. Diphenyl diselenide (PhSe) 2 improves the antioxidant response via activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like ECH-associated protein (keap 1) pathway in macrophage cells. In the … WebOct 24, 2024 · Tellurium is a rare element that has been regarded as a toxic, nonessential element, and its biological role is not clearly established. In addition, the biological effects of elemental tellurium and some of its organic and inorganic derivatives have been studied, leading to a set of interesting and promising applications. Diphenyl ditelluride (DPDT), an …

Diphenyl diselenide reduces inflammation in the mouse model of ... - PubMed

WebFeb 1, 2003 · Administration of 200 μmol/kg diphenyl diselenide (i.p.) induced 100% seizures in mice and caused 50% death in 72 h. All mice died after doses higher than 350 μmol/kg of diphenyl diselenide. At lower doses (25–150 μmol/kg), no seizures were observed. The LD 50 calculated and the 95% confident interval was 210 μmol/kg … WebSep 1, 2010 · The results suggest that (PhSe)2 may be useful for the treatment of cognitive impairment that may hold significant therapeutic value in alleviating certain memory deficits observed in Alzheimer's disease. This study was conducted to evaluate the effects of exposure to diphenyl diselenide (PhSe)2 on cognitive impairment induced by … research volume

Diphenyl diselenide derivatives inhibit microbial biofilm …

WebAug 13, 2013 · A later study of the latter research group showed that daily treatment with diphenyl diselenide (5 lmol/kg) prevented MeHg-induced brain mitochondrial dysfunction, oxidative stress and reduction ... WebDec 11, 2013 · The acute liver failure (ALF) induced by acetaminophen (APAP) is closely related to oxidative damage and depletion of hepatic glutathione, consequently changes in cell energy metabolism and mitochondrial dysfunction have been observed after APAP overdose. Diphenyl diselenide [(PhSe)2], a simple organoselenium compound with … pro sports mvp marketing colorado

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Toxicology and pharmacology of synthetic organoselenium

WebAug 13, 2013 · A later study of the latter research group showed that daily treatment with diphenyl diselenide (5 lmol/kg) prevented MeHg-induced brain mitochondrial dysfunction, … WebThe aim of this study was to verify the effect of diphenyl diselenide (PhSe) 2 on hepatic nucleotidases and on the concentration of purines in mice infected by Toxoplasma gondii. … research vs analysisWebDiphenyl diselenide (Ph 2 Se 2) is an organoselenium compound. Its crystalline structure, toxicokinetic properties, antioxidant and anti-inflammatory activities have been … research vocabulary terms

"WebDiphenyl diselenide-modulation of macrophage activation: Down-regulation of classical and alternative activation markers Lucı´a L Rupil1,2, Andreza F de Bem2 and German A Roth1 Abstract Diphenyl diselenide (PhSe) 2, a simple organoselenium compound, possesses interesting pharmacological properties that are under extensive research. " - Topical diphenyl diselenide mice research

Topical diphenyl diselenide mice research

p,p′-Methoxyl-diphenyl diselenide-loaded polymeric

WebJan 20, 2024 · It was observed that diphenyl diselenide was less toxic in rats than in mice—the LD 50 of this compound was 374.4 mg/kg in rats and 65.52 mg/kg in mice after … WebFeb 1, 2003 · Administration of 200 μmol/kg diphenyl diselenide (i.p.) induced 100% seizures in mice and caused 50% death in 72 h. All mice died after doses higher than 350 …

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WebOct 28, 2010 · Since the successful use of the organoselenium drug ebselen in clinical trials for the treatment of neuropathological conditions associated with oxidative stress, there … WebAldrich-180629; Diphenyl diselenide 0.98; CAS No.: 1666-13-3; Synonyms: Phenyl diselenide; Linear Formula: C6H5SeSeC6H5; Empirical Formula: C12H10Se2; find related products, papers, technical documents, MSDS & more at Sigma-Aldrich. ... Our team of scientists has experience in all areas of research including Life Science, Material Science, ...

WebMice were pretreated with Se-PTC (1–50 mg/kg), via the peroral route (p.o), 0.5 h before injection with acetate. Control animals received a similar volume of the vehicle (10 ml/kg, canola oil) as the negative, or Celecoxib(150 mg/kg,p.o.)asthepositivecontrol.Post-challenge,the mice were placed individually into separate boxes and the total Weboxyl-diphenyl diselenide, (p-Cl-C H Se) – p-chloro-diphenyl dise-lenide, (PhSe) – diphenyl diselenide, PTZ – pentylenetetra zole) Introduction Among the different neurological disorders that affect the human condition, epilepsy has been largely stud-ied during the last century [16, 27] and has become a dynamic research field in recent ...

WebAug 1, 2016 · Diphenyl Diselenide Reduces Oxidative Stress and Toxicity Caused by HSV-2 Infection in Mice: Diphenyl diselenide decreases HSV-2 toxicity August 2016 Journal of … WebAcademia.edu is a platform for academics to share research papers. An organic selenium compound attenuates apomorphine-induced stereotypy in mice ... N. Schroder, I. Izquierdo, J.A. Henriques, R. Roesler, Differ- administration of diphenyl diselenide in mice, Neurosci. Lett. 341 (2003) ential neurobehavioral deficits induced by apomorphine and ...

WebDec 25, 2024 · Exposure to pesticide chlorpyrifos (CPF) is associated with neurodevelopmental toxicity both in humans and animals. Diphenyl diselenide (DPDS) is a …

WebSep 21, 2016 · Research article; Open Access; Published: ... The prevention of biofilm formation is the goal of wound treatment because the standard protocols based on … pro sports in atlantaWebThe present study evaluated the comparative toxicological effects of diphenyl diselenide (PhSe) 2 and diphenyl ditelluride (PhTe) 2 in mice after in vivo administration. … prosport softwareWebDiphenyl diselenide (Ph 2 Se 2) is an organoselenium compound.Its crystalline structure,[] toxicokinetic properties,[] antioxidant and anti-inflammatory activities have been investigated.[] Its ability to reverse the oxidative brain damage and mitochondrial dysfunction induced by acetaminophen has been studied in mice.[] It reacts with thallium … pro sports in kentuckyWebBackground: Candida auris is an emergent fungal pathogen and a global concern, mostly due to its resistance to many currently available antifungal drugs. Objective: Thus, in response to this challenge, we evaluated the in vitro activity of potential new drugs, diphenyl diselenide (PhSe)2 and nikkomycin Z (nikZ), alone and in association with currently … pro sportsman drag carWebAug 25, 2024 · Diphenyl diselenide was effective against 32 Aspergillus isolates (MIC 64 µg mL −1 ), which increased the fungicidal action of the drug caspofungin, but was ineffective against an aspergillosis ... prosportsortho.comWebOct 1, 2024 · Moreover, topical treatment with the hydrogel containing (OMePhSe) 2 loaded-nanocapsules was more effective in reducing ear thickness and the inflammatory … pro sports on tv tonightWebMay 15, 2012 · The odor of diphenyl diselenide is extremely disagreeable but is not nearly so bad as that of selenophenol. The effect of selenophenol on the skin is very similar to that … research volunteering uk