Nettet1. okt. 2024 · Based on studies of Thbs1 null mice, platelet THBS1 is not essential for platelet aggregation, but THBS1 null mice have impaired excisional but improved ischemic wound repair, increased retinal angiogenesis, and are hyper-responsive to several inflammatory stimuli (Soto-Pantoja et al., 2015). time stimulates pathologic production … NettetHomozygous null mice show partial prenatal lethality, lordosis, kyphosis, leukocytosis, multiorgan inflammation, lung hemorrhage, pneumonia, resistance to radiation and …
THBS1 regulates trophoblast fusion through a CD36
Nettet21. mar. 2024 · GeneCards Summary for THBS1 Gene. THBS1 (Thrombospondin 1) is a Protein Coding gene. Diseases associated with THBS1 include Thrombotic … Nettet30. mai 2024 · Abstract In this study, the effect of the THBS1 gene knockout on the survival of human tumor cells, the frequency of spontaneous and radiation-induced micronuclei, and the expression profile of genes in the HeLa cell line was investigated. It was shown that the THBS1 gene knockout led to a decrease in the plating efficiency … meg walks collingwood
Thrombospondin-1 triggers macrophage IL-10 production and …
All experimental procedures with animals were approved by the Institutional Animal Care and Use Committee (IACUC) of Cincinnati Children’s Medical Center, protocols IACUC 2016-0069 and 2024-0047. The number of mice used in this study reflects the minimum number needed to achieve statistical significance based on … Se mer Full-length mouse Atf4 cDNA was obtained from Addgene (plasmid #21845, deposited by Dr. David Ron), amplified by PCR using CloneAMP HiFi PCR premix (Takara Bio, #639298) and cloned into the Cla1 and XhoI sites of … Se mer Adenoviruses harboring Thbs1, Thbs3, tandem mRFP-GFP-LC3 (Ad-tf-LC3; gift from Dr. J. Sadoshima of the University of Medicine and Dentistry of New Jersey, Newark), and β-galactosidase (βgal) expressing control were … Se mer Hearts were excised, immediately frozen in liquid nitrogen and stored at −80 °C until further use. Cultured primary NRVMs were washed three times … Se mer Protein extracts from tTA cont. and Thbs1 DTG hearts were generated by homogenizing in immunoprecipitation (IP) lysis buffer (50 mM Tris-HCl pH 7.4, 150 mM NaCl, 1% Triton X … Se mer Nettet4. apr. 2024 · Thrombospondin-1 induced programmed death-ligand 1-mediated immunosuppression by activating the STAT3 pathway in osteosarcoma. Role of … Nettet10. jun. 2008 · 188060 - THROMBOSPONDIN I; THBS1 - TSP1 - THBS1 To explore the function of thrombospondin I in vivo, Lawler et al. (1998) disrupted the Thbs1 gene by homologous recombination in the mouse genome. Platelets from these mice were completely deficient in Thbs1 protein; however, thrombin-induced platelet aggregation … meg walter the beehive