Ctcf disease
WebCTCF-related neurodevelopmental disorder Disease definition A rare, genetic, neurodevelopmental disorder characterized by global developmental delay, … WebApr 12, 2024 · These data collectively indicated that our catalog represents a high-quality map of STR variation for humans. In total, our analysis identified 366,013 pSTRs in the 6487 WGS samples, with 306,602 ...
Ctcf disease
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WebMay 30, 2024 · CCCTC-binding factor (CTCF) is an architectural protein that can mediate both interchromosomal and intrachromosomal interactions. The functional outcomes of … WebNational Center for Biotechnology Information
WebThe application of these methods manifested that, upon CTCF loss, TADs and CTCF-mediated loops disappear in a dosage-dependent manner, but segregation into A/B compartments is largely preserved. These results not only demonstrate the critical function of CTCF in 3D genomic organization, but also the independent action of transcription … WebJan 1, 2024 · Results. Liver-specific, CTCF-deficient mice developed hepatic steatosis and inflammation when fed a standard chow diet. Global analysis of the transcriptome and enhancer landscape revealed that CTCF-depleted liver showed enhanced accumulation of PPARγ in the nucleus, which leads to increased expression of its downstream target …
WebCTCF (CCCTC-Binding Factor) Polyclonal Antibody validated in ChIP-seq, ChIP-qPCR, WB, IF and ELISA. Specificity confirmed by siRNA assay. ... Bansal, A and Balasubramanian, S and Dhawan, S and Leung, A and Chen, Z andNatarajan, R Diabetic kidney disease (DKD) is a major complication of diabetes and the leading cause of end-stage renal failure ... WebApr 13, 2024 · MYC reshapes CTCF-mediated chromatin architecture in prostate cancer. April 13, 2024. MYC is a well characterized oncogenic transcription factor in prostate cancer, and CTCF is the main architectural protein of three-dimensional genome organization. However, the functional link between the two master regulators has not been reported.
Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation of … See more CCCTC-Binding factor or CTCF was initially discovered as a negative regulator of the chicken c-myc gene. This protein was found to be binding to three regularly spaced repeats of the core sequence CCCTC and thus … See more The primary role of CTCF is thought to be in regulating the 3D structure of chromatin. CTCF binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular structures like the nuclear lamina. It also defines the boundaries between active and … See more CTCF binds to itself to form homodimers. CTCF has also been shown to interact with Y box binding protein 1. CTCF also co-localizes with cohesin, which extrudes chromatin loops by … See more • CCCTC-binding+factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook CTCF See more The binding of CTCF has been shown to have many effects, which are enumerated below. In each case, it is unknown if CTCF directly evokes the outcome or if it does so indirectly (in … See more CTCF binds to the consensus sequence CCGCGNGGNGGCAG (in IUPAC notation). This sequence is defined by 11 zinc finger motifs in its structure. CTCF's binding is disrupted by See more • Ohlsson R, Renkawitz R, Lobanenkov V (2001). "CTCF is a uniquely versatile transcription regulator linked to epigenetics and … See more
WebJul 8, 2024 · CTCF is known as a master chromatin regulator 41,42, and we observed that the CTCF motif variability trajectory was anti-correlated with the DAA and GFAP-high signatures (end of the trajectory ... instance segmentation mask apWebDNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8 + T cells Immunity. 2024 Apr 5;S1074-7613 (23)00137 ... jimmy wan\u0027s restaurant and loungeWebheart failure: Definition Heart failure is a condition in which the heart has lost the ability to pump enough blood to the body's tissues. With too little blood being delivered, the … instance seriesWebJul 6, 2024 · In a recent work, CTCF binding sites surrounding the well-known ZRS enhancer of the Shh gene (see above) were removed by CRISPR-mediated genome editing in mice. Strikingly, the lack of these CTCF binding sites reduced the interaction between ZRS and Shh promoter, as well as the expression of the latter (Paliou et al., 2024). … instance sequence matchingWebCTCF-related neurodevelopmental disorder Disease definition A rare, genetic, neurodevelopmental disorder characterized by global developmental delay, borderline to severe intellectual disability, feeding difficulties, behavioral anomalies, vision anomalies and mild facial dysmorphism. instance security centerWebMutations in CTCF binding sites at the Igf2/H19 locus have been identified in patients with Beckwith-Wiedemann syndrome, an overgrowth disorder predisposing patients to … instance segmentation toolWebJan 16, 2024 · Specifically, CTCF has been demonstrated to regulate the clustered gene families such as HOX, protocadherin, and β-globin through the organization of chromatin structures [[20-22]]. DNA methylation, which is involved in a wide range of gene expression during development and disease, is known to affect the CTCF-DNA binding occupancy []. instanceserverg